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Extended Bio

Harry is passionate about supporting individuals and families through the process of genetic testing and helping them understand the implications of any results, so that they can decide their own best next steps forwards. He will provide support to our genetic counselling team for complex cases and be available for individual appointments when necessary.

He is also the Lead for Clinical Genetics at Jeen Health, working closely with the team at London Pregnancy Clinic. Together, they support patients and families with clear, evidence-led genetic guidance during pregnancy and beyond.

Dr Leitch’s academic work explores early human development, including how genetic and epigenetic changes shape the germline cycle. He also studies how disruption in early development can contribute to severe infertility or germ cell tumours, using stem cell models to validate genomic findings. Clinically, he specialises in paediatric rare disease genetics, helping families understand complex results and next steps with care and clarity.

Medical qualifications/specialisations

  • 2025 – Fellow of the Higher Education Academy (FHEA)
  • 2023 – Postgraduate Certificate in the Interpretation and Clinical Application of Genomic Data, University of London
  • 2022Royal College of Pathologists Certificate in Medical Genetics
  • 2019 – Member of the Royal College of Paediatrics and Child Health (MRCPCH)
  • 2014 – Bachelor of Medicine, Bachelor of Surgery (MBBS), University of Cambridge
  • 2012 – Doctor of Philosophy (PhD), University of Cambridge (Supervisors: Austin Smith and Azim Surani)
  • 2010 – Master of Arts (MA), University of Cambridge
  • 2007 – Bachelor of Arts (BA), Natural Sciences Tripos Part II in Physiology, Development and Neuroscience, University of Cambridge (First Class)

What I’m most excited to bring to Spital Clinic members

Coming Soon!

Ask me about...

  • General genetics
  • Rare disease genetics
  • Paediatric genetics
  • Dysmorphology, birth defects, developmental delay, intellectual disability
  • Interpretation of genomic test resultsFamily follow-up testingGenetics of infertility
  • Family follow-up testing
  • Genetics of infertility

Most likely to find me

Harry is a former Scottish international squash player, competing at three Commonwealth Games, three World Team Championships & six European Team Championships (70 caps). He holds the University of Cambridge record for most Blues in a single sport – 10 Blues in squash.

2006 Commonwealth Games: quarterfinals (doubles).
2010 Commonwealth Games: 4th place (doubles), quarterfinals (mixed doubles).
2014 Commonwealth Games: 4th place (doubles).

And yes, coming 4th is the worst!

Publications

  • 2024 Sepulveda-Rincon LP, Wang YF, Whilding C, Ojarikre OA, Turner JMA, Leitch HG. Interrogating the potential of primordial germ cells by injection into early mouse embryos. Developmental Cell 59, 695-704.e5
  • 2024 Shah P, Hill R, Dion C, Clark SJ, Abakir A, Willems J, Arends MJ, Garaycoechea JI, Leitch HG, Reik W, Crossan G. Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nature Communications 15, 3734
  • 2022 Peshimam N, Farah H, Caswell R, Ellard S, Jan W, Calder AD, Cobben J, Kariholu U, Leitch HG. Sedaghatian spondylometaphyseal dysplasia
  • 2021 Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima T, Ito T, Leitch HG, Hayashi K. Reconstitution of the oocyte transcriptional network with transcription factors. Nature 286, 493-6.
  • 2021 Posfai E, Lanner F, Mulas C, Leitch HG. All models are wrong, but some are useful: establishing standards for stem cell-based embryo models. Stem Cell Reports 16(5):1117-1141
  • 2021 Ramakrishna NB, Murison K, Miska EA, Leitch HG. Epigenetic Regulation during Primordial Germ Cell Development and Differentiation. Sexual Development 15(5-6):411-431
  • 2018 Hill PWS, Leitch HG*, Sun Z*, Requena-Torres C*, Amouroux R*, Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the primordial
    germ cell-to-gonocyte transition in mouse. Nature 555(7696), 392–396
  • 2018 Zhang M*, Leitch HG*, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I#. Esrrb complementation rescues development of Nanog-null germ cells. Cell Reports 9;22(2), 332-9
  • 2013 Leitch HG, Nichols J, Humphreys P, Mulas C, Martello G, Lee C, Jones K, Surani MA and Smith A. Rebuilding pluripotency from primordial germ cells. Stem Cell Reports 1(1), 66-78
  • 2013 Leitch HG*, McEwen KR*, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA and Hajkova P. Naïve pluripotency is associated with global DNA hypomethylation. Nature Structural & Molecular Biology
    20, 311–316

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